Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TNF receptor associated factor (TRAF) family members, and to activate c-Jun N-terminal kinases (JNK) signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
See also
- Mitogen-activated protein kinase for JNK signaling pathway description
References
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
